WebAlthough ALK has been associated with high-risk neuroblastoma and a variety of ALK inhibitors are available, none of these are currently approved to treat ALK-positive neuroblastoma. In fact, ALK -mutated tumours can be highly susceptible to resistance to first-generation tyrosine kinase inhibitor therapies, such as crizotinib, or second ... WebApr 10, 2024 · ALK in Neuroblastoma: Biological and Therapeutic Implications. Neuroblastoma (NB) is the most common and deadly solid tumour in children. …
ALK inhibitors for ALK -altered paediatric malignancies
WebApr 4, 2024 · Purpose: ALK-activating mutations are identified in approximately 10% of newly diagnosed neuroblastomas and ALK amplifications in a further 1%–2% of cases. Lorlatinib, a third-generation anaplastic lymphoma kinase (ALK) inhibitor, will soon be given alongside induction chemotherapy for children with ALK-aberrant neuroblastoma. WebApr 3, 2024 · In 2008, Dr. Mossé and colleagues discovered that the anaplastic lymphoma kinase (ALK) gene causes most cases of rare, inherited neuroblastoma. Since then, she and colleagues from around the world have investigated how mutations in the ALK gene lead to different types of nonhereditary neuroblastoma. scott lynch blue cross and blue shield of mn
Clinical trial may change the paradigm of care for patients with ALK ...
WebDec 30, 2024 · Mechanistically, inhibition of p110α decreased anaplastic lymphoma kinase (ALK) in neuroblastoma cells by decreasing its protein stability. Conclusions In this study, we investigated the oncogenic roles of PI3K isoforms in neuroblastoma. WebGiven mutant ALK has been successfully targeted in other diseases such as in anaplastic large-cell lymphoma, non-small-cell lung cancer and myofibroblastic sarcoma, ALK has … WebJan 1, 2024 · In past decades, some promising treatments for neuroblastoma have been studied and advanced in clinical trials. Treatments include tyrosine kinase inhibitors (e.g., anaplastic lymphoma kinase [ALK] inhibitors) and norepinephrine-targeted agents (e.g., 131I-metaiodobenzylguanidine [MIBG]). prescot gates