Circrhobtb3
WebcircRHOBTB3是通过宿主基因RHOBTB3的剪接和环化产生的。 作为Rho GTPase家族的ATPase，宿主基因RHOBTB3参与膜转运和蛋白酶体降解，可通过促进肾癌中HIF-α的蛋白酶体降解来抑制肿瘤生长。 先前的研究还表明circRHOBTB3在卵巢癌、胃癌、CRC和肝细胞癌（HCC）中是一种肿瘤抑制性circRNA。 然而，其环化模式和外泌体分泌途径尚不明 … Webdetecting both circRHOBTB3 and RHOBTB3 (Fig. 1D). en, the specic back-splicing site of circRHOBTB3 was identied by RT-PCR and Sanger sequencing (Fig. 1E). Compared with the linear host genes RHOBTB3 and GAPDH, circRHOBTB3 signicantly resisted RNase R treatment (Fig. 1F). en, we detected the expres-sion of circRHOBTB3 in serum from 18 …
Circrhobtb3
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WebJun 2, 2024 · The molecular mechanism of circRHOBTB3 inhibits the proliferation and invasion of epithelial ovarian cancer by serving as the ceRNA of miR-23a-3p Rising evidences bespeak that circular RNAs are indispensable in regulating cellular biological behaviors and engaging in diseases' occurrence. WebJul 27, 2024 · We aimed to explore the functional role of circular RNA RHOBTB3 (circRHOBTB3) in ovarian cancer. The expression of circRHOBTB3 was detected by real-time quantitative PCR (RT-qPCR). Then, the localization of circRHOBTB3 in ovarian cancer cells was identified by cell fractionation assay.
WebFeb 11, 2024 · circRHOBTB3 is secreted outside of tumor cells and suppresses CRC cells in vitro and in vivo. ( A) Expression of circRHOBTB3 in CRC or normal colonic epithelial … WebFeb 11, 2024 · circRHOBTB3 is secreted outside of tumor cells and suppresses CRC cells in vitro and in vivo. (A) Expression of circRHOBTB3 in CRC or normal colonic epithelial …
WebMar 21, 2024 · CircRHOBTB3 interacted with the RNA-binding protein, IGF2BP3, to stabilize its expression in CC cells and is putatively transcriptionally regulated by NR1H4. In conclusion, this novel NR1H4/circRHOBTB3/IGF2BP3 axis may provide new insights into CC pathogenesis. PMID: 36939994 WebDescription. Bloodhound XTN #3, spare set of bushings and replacement retention mechs, magnetic off wand, and nock of each: flat, “v”, and capture
WebFeb 11, 2024 · Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer Jiaxin Chen, Yizheng Wu, +9 authors Zhangfa Song Biology, Medicine Theranostics 2024 TLDR Findings indicate that circRHOBTB3 exerts suppressive effects on CRC aggressiveness through the …
WebNR1H4-mediated circRHOBTB3 modulates the proliferation, metastasis, and Warburg effects of cervical cancer through interacting with IGF2BP3 Mol Cell Biochem. 2024 Mar 20. doi: 10.1007/s11010-023-04692-5. Online ahead of print. Authors Ailing Ren # 1 , Fan Gong # 2 , Guokun Liu 3 , Wenli Fan 4 Affiliations orangutan foundationWebNational Center for Biotechnology Information orangutan from the jungle bookWebOverexpression of circRHOBTB3 suppresses tumor metastasis in CRC cells. Mechanistically, circRHOBTB3 binds to HuR, which is a ubiquitously expressed and … orangutan full grownWebView 10 photos for 263 Crestwood Cir, Benton, LA 71006, a 2 bed, 2 bath, 1,064 Sq. Ft. single family home built in 1984 that was last sold on 10/29/2024. ipl fs 250WebMechanistically, circRHOBTB3 binds to HuR, which is a ubiquitously expressed and functional RNA-binding protein (RBP) in CRC development, and promotes β-Trcp1-mediated ubiquitination of HuR. Normally, HuR binds to the 3'UTR of target mRNAs to facilitate their stabilization, whereas the interaction between circRHOBTB3 and HuR degrades HuR to ... ipl fs 85WebJan 13, 2024 · Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth Taken together, this study revealed that circRHOBTB3 might … orangutan giving birth videoWebing in diseases’ occurrence. CircRHOBTB3 has been reported to participate intimately in the progression of some cancers. Nevertheless, the mechanism by which circRHOBTB3 regulates tumorigenesis in epithelial ovarian cancer (EOC) remains ill-dened. The present study determined the expression pattern and bio-eects of circRHOBTB3 in EOC. orangutan genus and species name