Cisplatin and sodium thiosulfate
WebSomani et al. 1995), sodium thiosulfate (Markman et al. 1991), S-2-(3-aminopropylamino)-ethyl phosphorothioic acid (WR2721) (Yuhas & Culo 1980), glutathione (GSH, ... WebFeb 14, 2024 · FDA approves sodium thiosulfate to reduce the risk of ototoxicity associated with cisplatin in pediatric patients with localized, non-metastatic solid tumors. …
Cisplatin and sodium thiosulfate
Did you know?
WebAug 2, 2024 · A randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head … WebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated.
WebJan 25, 2008 · Purpose: We determined if the potentially otoprotective agent sodium thiosulfate (STS) could be given 6 h after cisplatin without diminishing the … WebDosing per FDA Guidelines. The recommended dose of sodium thiosulfate (e.g., Pedmark) is based on body surface area according to actual body weight as summarized below …
WebThe major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral … WebNov 22, 2024 · The drugs sodium thiosulfate and mannitol may protect against cisplatin-induced hearing loss. Specifically, sodium thiosulfate has been found to protect the cells in the inner ear, and may therefore prevent hearing loss. Mannitol can help sodium thiosulfate enter the inner ear, and ponteially increase the effectiveness of sodium …
WebSodium thiosulfate interacts directly with cisplatin to produce an inactive platinum species; In addition, sodium thiosulfate can enter cells through sodium sulfate cotransporter 2 …
WebFeb 1, 2024 · Sodium thiosulfate is also used to reduce the risk of hearing loss in children 1 month of age and older who are receiving medicines (eg, cisplatin) for cancer that have not spread throughout the body. This medicine is to be given only by or under the immediate supervision of your doctor. This product is available in the following dosage forms: chipotle career sign inWebFeb 1, 2024 · Proper Use. Pedmark®: A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins. It must be given slowly, so the needle will need to stay in place for at least 15 minutes. This medicine is given 6 hours after receiving cancer medicine (eg, cisplatin). chipotle career pathWebObjectives: To determine safety, feasibility, and preliminary activity of transtympanic injection of sodium thiosulfate (STS) against cisplatin-induced hearing loss (CIHL). … chipotle careers log inWebJul 13, 2024 · Of the 101 participants, hearing loss occurred in 29 (63%) of the children who received cisplatin alone, compared with 18 (33%) of those who also got sodium … grant thornton philadelphiaWebFeb 1, 2024 · This medicine is given 6 hours after receiving cancer medicine (eg, cisplatin). You may also receive other medicine (eg, allergy medicine, steroid medicine) or … grant thornton peruWebcompared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects … chipotle calories listWebFeb 17, 2024 · Cisplatin extravasation, concentrated: Infants, Children, and Adolescents: Inject 2 mL of a 1/6 M (~4%) sodium thiosulfate solution into existing IV line for each 100 mg of cisplatin extravasated; consider also injecting 1 mL of a 1/6 M (~4%) sodium thiosulfate solution as 0.1 mL subcutaneous injections (clockwise) into the area around … chipotle careers online application