WebFeb 17, 2024 · Cisplatin inhibits DNA synthesis by the formation of DNA cross-links; denatures the double helix; covalently binds to DNA bases and disrupts DNA function; may also bind to proteins; the cis -isomer is 14 … WebOccasionally reactions secondary to cisplatin therapy have been reported. Patients receiving cisplatin should be observed carefully for possible anaphylactic-like reactions and the necessary equipment and medication should be readily available to treat such reactions. Patients with a family history of atopy are at particular risk.
CISPLATIN: ITS HISTORY AND POSSIBLE MECHANISMS OF ACTION
WebJul 1, 2024 · History of cisplatin motivates researcher about explanation of negative observation. • Knowledge of synthesis and purification of cisplatin are useful for medical … WebNov 21, 2024 · However, cisplatin is also used to fight brain tumors. The actual chemical compound of cisplatin is cis - [Pt (NH3)2Cl2] and was identified by Michele Peyrone in 1845, known at that time as ... lee tillman houston
CISPLATIN: ITS HISTORY AND POSSIBLE MECHANISMS OF …
WebThe Italian chemist Michele Peyrone first reported cisplatin synthesis in 1844 (ref. 3), but the biological activity of cisplatin was shown for the first time in 1965, when Barnett Rosenberg and ... WebJul 18, 2024 · Cisplatin Brand name: Platinol-AQ Drug class: Antineoplastic Agents - Platinum-containing Agents VA class: AN900 Chemical name: (SP-4-2)-Diamminedichloroplatinum Molecular formula: Cl 2 H 6 N 2 Pt CAS number: 15663-27-1 Medically reviewed by Drugs.com on Jul 18, 2024. Written by ASHP. Introduction Uses … WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying … lee tanis