Cthrc1 fibrosis
WebTreatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease Author links open overlay panel Zhaolian Bian a 1 , Qi Miao a 1 , Wei Zhong a 1 , Haiyan Zhang a , Qixia Wang a , Yanshen Peng a , Xiaoyu Chen a , Canjie Guo a , Li Shen a , Fan Yang a , Jie Xu a , Dekai Qiu a ... WebSep 25, 2024 · To determine whether cluster B can be identified in other models of cardiac fibrosis, we examined the presence of CTHRC1 + CFs in a model of chronic cardiac …
Cthrc1 fibrosis
Did you know?
WebJan 11, 2024 · There is evidence to indicate that collagen triple helix repeat containing 1 (CTHRC1), a secreted protein, is involved in many physiological and pathological … WebJan 11, 2024 · We demonstrated that CTHRC1 is a new regulator of liver fibrosis by modulating TGF-β signaling. Targeting CTHRC1 could be a promising therapeutic approach, which can suppress TGF-β signaling …
WebNature Genetics 南模生物助力揭示心内膜起源的成纤维细胞调控心脏纤维化. 心力衰竭每年都会导致全球范围内大量的个体致病或死亡。. 在心脏损伤早期，心脏成纤维细胞被激活并分化成具有收缩性的肌成纤维细胞，产生大量的胞外基质，生成富含胶原的疤痕 ... WebSep 30, 2016 · CTHRC1 (collagen triple-helix repeat-containing 1), a protein secreted during the tissue-repair process, is highly expressed in several malignant tumors, including pancreatic cancer. We recently ...
WebCthrc1 −/− animals have decreased lung function following bleomycin-induced fibrosis The rise in hydroxyproline was somewhat reflected in the measures of lung compliance. Bleomycin injection decreased lung … WebFibrosis is mainly triggered by inflammation in various tissues, such as heart and liver tissues, and eventually leads to their subsequent dysfunction. Fibrosis is characterized …
WebSep 23, 2024 · CTHRC1 is a secreted protein involved in a variety of processes, including vascular remodeling, anti-fibrosis, metabolism, and carcinogenesis. ... Wu Q, Yang Q, Sun H. Collagen triple helix repeat containing-1: a novel biomarker associated with disease activity in systemic lupus erythematosus. Lupus. 2024;27(13) ...
WebMay 18, 2024 · Collagen triple helix repeat containing-1 (CTHRC1) is a highly conserved extracellular matrix glycoprotein that is overexpressed in two murine models of cholestatic liver fibrosis. Elevated CTHRC1 has been found to attenuate liver fibrosis in these murine models, thus we aimed to study the expression of CTHRC1 in patients with cholestatic … highland hollywood mallWebDec 29, 2024 · Keloid may induce severe impairment of life quality for the patients, although keloid is a cutaneous benign tumor. Collagen triple helix repeat containing protein 1 (Cthrc1) was identified as a novel gene that was originally found in adventitial fibroblasts after arterial injury. To address the role of Cthrc1 in keloid, the expression level of Cthrc1 was … highland hollywoodWebJan 11, 2024 · There is evidence to indicate that collagen triple helix repeat containing 1 (CTHRC1), a secreted protein, is involved in many physiological and pathological processes. In the progression of liver fibrosis, in which the activation of hepatic stellate cell (HSCs) is considered as the central event, the role of CTHRC1 remain unclear and need to ... highland home bank highland home alWebNational Center for Biotechnology Information highland home elementary schoolWebCollagen triple helix repeat containing 1 (CTHRC1), a glycoprotein, is involved in multiple pathological processes, including inflammation and fibrosis. However, the function of CTHRC1 in asthma ... highland home cemetery jamestownWebMar 1, 2013 · Fibrosis is the main complication of muscular dystrophies. We identified collagen triple helix repeat containing 1 (Cthrc1) in skeletal and cardiac muscles of mice, representing Duchenne and congenital muscle dystrophies (DMD and CMD, respectively), and dysferlinopathy. highland hollow boise idahoWebTissue stiffness is increased during lung fibrosis, which coincides with a transition of fibroblasts into ACTA2+/CTHRC1+ contractile myofibroblasts that secrete large amounts … highland hollywood ca