WebAn orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Sheddase inhibitor INCB007839 represses the metalloproteinase ""sheddase"" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. http://www.fluoroprobe.com/archives/tag/atf
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WebINCB007839 related products. MedChemExpress provides thousands of inhibitors, modulators and agonists with high purity and quality, excellent customer reviews, precise and professional product citations, tech support and prompt delivery. WebDescription: Aderbasib, also known as INCB007839, is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of … fishing bridge yellowstone history
Safety and Efficacy of INCB007839 With Trastuzumab and …
WebAderbasib (formerly INCB-7839; INCB007839) is a novel, orally bioactive, and potent sheddase inhibitor with potential anticancer activity. It also inhibits ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins. WebSponsors: Lead Sponsor: Incyte Corporation Source: Incyte Corporation Brief Summary: This is a single arm, modified dose escalation, open label trial with the objectives of: (1) Determining a safe optimal dose of INCB007839 in combination with trastuzumab and docetaxel (2) Determining clinical efficacy and safety of INCB007839 in combination with … WebThis phase I trial studies the side effects and best dose of aderbasib (INCB007839) in treating patients with high-grade glioma that has come back (recurrent) or that is growing, … fishing bridge rv park check in