WebINF7 was therefore se-lected for coupling to a high affinity ligand for the asia-loglycoprotein receptor (ASGPr), K(GalNAc) 2,toim-prove its uptake by parenchymal liver cells. … Web19 mei 2011 · Effect of lysosomal (INF7) peptide on transfection efficiency of P(DMAEMA-co-OEGMA) gene vector complexes on BEAS 2B cells. Plasmid DNA or mRNA polyplexes and ternary complexes were prepared with P(DMAEMA- co -OEGMA) copolymer (8% OEGMA and 9 EG units) at N/P ratio of 40 in HBS, respectively.
Co-encapsulating the fusogenic peptide INF7 and molecular …
Web27 mrt. 2015 · The INF7 peptide is a glutamine-enriched analogue of the membrane-disruptive segment of HA2 (amino acids 1–23) that exhibits greater pH sensitivity and … Web31 mei 2024 · Peptide 6 (INF7-Tat) [24,25] was the most potent of these analogs at pH 5.5, while also maintaining the 3-fold pH selectivity of the lead peptide, and this peptide also … trailing apricot begonias
Investigating the pharmacodynamic durability of GalNAc–siRNA …
WebThe present study aimed to determine how two different EEPs, INF7 and H5WYG, which destabilize the endosomal membrane at different pHs, affect the efficiency of PEG-based … WebTwo peptides (INF7 and JTS-1) were tested for their capacity to disrupt liposomes. In contrast to JTS-1, INF7 induced rapid cholesterol-independent leakage (EC 50, 1.3 μ m). … Web21 dec. 2007 · •The engineered MyoD-IT showed efficient nuclear targeting through an endosomal escape by INF7 peptide. •By applying MyoD-IT, human adipose-derived … trailing arbutus flower