Irf3 transcription factor
WebTranscription factors IRF3 activates toll-like receptor-independent type I IFN production, which are very important in inducing IFN-γ production. 32 IFN-α/β is one of the most … WebJan 8, 2024 · The mammalian IRF family proteins are structurally related transcription factors consisting of nine members: IRF1, IRF2, IRF3, IRF4 (also called ICSAT [IFN consensus sequence-binding protein for activated T-cells], LSIRF [lymphocyte-specific IRF], PIP [PU.1-interacting protein]), IRF5, IRF6, IRF7, IRF8 (also referred to ICSBP [IFN …
Irf3 transcription factor
Did you know?
WebMay 27, 2024 · Thereafter, TBK1 in this signalosome phosphorylates C-terminus of interferon regulatory factors 3 (IRF3), which mobilizes IRF3 for dimerization and nuclear translocation, where it functions as transcription factor to induce the expressions of type I interferons (IFN-Is), various cytokines, and subsequently a multitude of IFN-stimulated … IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association … See more Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor. See more IRF3 has been shown to interact with IRF7. See more • Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth" See more • Interferon+Regulatory+Factor-3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook IRF3 See more
WebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … WebMar 9, 2024 · IRF3 is a major transcriptional regulator of adipose inflammation and is involved in maintaining systemic glucose and energy homeostasis Findings indicate that STING-TBK1-IRF3 pathway mediates a crosstalk between ER stress and apoptosis during M. bovis infection, which can effectively control intracellular bacteria.
WebMay 31, 2024 · IRF3 (interferon regulatory factor 3) is one of the most critical transcription factors in antiviral innate immune signaling, which is ubiquitously expressed in a variety of cells. WebThe infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation of the transcription factor interferon regulatory factor 3 (IRF3) and consequent induction of host immune responses to RNA viruses.
WebApr 11, 2024 · TLR signaling cascades typically converge on transcription factors such as NFκB, AP-1, and IRF3 that initiate the synthesis of a battery of innate immune effectors involved in antibacterial ...
WebMay 31, 2024 · IRF3 (interferon regulatory factor 3) serves as an indispensable transcription factor for type I IFN production. After receiving upstream signals, IRF3 goes through diverse processes to activate the type I IFN signaling, including phosphorylation, dimerization, translocation to nucleus and stimulation of DNA binding and transcriptional activity ... how do you know when you\u0027re drunkWebIRF-3 is expressed constitutively in a variety of tissues, and the relative levels of IRF-3 mRNA do not change in virus-infected or IFN-treated cells. Following virus infection, IRF-3 is … phone camcorder attachmentWebMay 31, 2024 · IRF3 (interferon regulatory factor 3) is one of the most critical transcription factors in antiviral innate immune signaling, which is ubiquitously expressed in a variety of … phone camera benchmarkWebJun 19, 2012 · Given that IRF3 acts as a transcription activator for promoters of genes encoding type I interferons but not for the Il12b promoter, it will be useful to explore the molecular mechanism by... how do you know when you pass a gallstoneWebThe transcription factor IFN regulatory factor 3 (IRF3) plays an essential role in this process (3, 4). It was also reported that IRF3 is required to protect the host from viral infections, … how do you know when you\u0027re hungryWebIRF-3 is expressed constitutively in a variety of tissues, and the relative levels of IRF-3 mRNA do not change in virus-infected or IFN-treated cells. Following virus infection, IRF-3 is posttranslationally modified by protein phosphorylation at multiple serine and threonine residues, located in the carboxy-terminus of IRF-3. how do you know when you see a tornadoWebNov 1, 2012 · IFN regulatory factor 3 (IRF3) regulates early type I IFNs and other genes involved in innate immunity. We have previously shown that cells undergoing an endoplasmic reticulum (ER) stress response called the unfolded protein response produce synergistically augmented IFN-β when stimulated with pattern recognition receptor … phone camera backlight