WebbNational Center for Biotechnology Information WebbAlthough LUBAC also regulates the apoptosis pathway, the precise mechanism by which LUBAC regulates apoptosis remains not fully defined. Here, we report that LUBAC-mediated M1-linked ubiquitination of cellular FLICE-like inhibitory protein (cFLIP), an anti-apoptotic molecule, contributes to tumor necrosis factor (TNF) α-induced apoptosis.
Frontiers The Balance of TNF Mediated Pathways Regulates …
WebbEffect ofTNF treatment on the induction of apoptosis in macrophages Next we checked if macrophages were induced to undergo apoptosis by treatment with TNF. Macrophages … Webb27 jan. 2024 · TNF-α is a double-edged sword for liver injury. Deletion of TNF-α or its receptor could alleviate LPS-induced liver injury but aggravate APAP-induced liver injury. … dv program.estate.gov
Apoptosis induced by nucleosides in the human hepatoma HepG2
Webb12 apr. 2024 · Functionally, circSmox silencing alleviated LPS-induced apoptosis and inflammation in PC12 cells in vitro. Mechanistically, circSmox directly sponged miR-340-5p, ... Moreover, the decreases of TNF-α, IL-1β, IL-6, and IL-8 levels in LPS-treated PC12 cells caused by miR-340-5p were rescued by Smurf1 upregulation ... WebbThe aim of this study is to investigate the role of tumor necrosis factor-α (TNF-α) in apoptosis and autophagy of mouse osteoblast MC3T3-E1 cells, as well as the crosstalk between autophagy and apoptosis. Mouse osteoblast MC3T3-E1 cells were cultured in vitro and treated with 5-fluorouracil (5-FU), rapamycin, 3-methyl adenine (3-MA) and TNF … Webb11 apr. 2024 · Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α; RIP3, an Energy Metabolism Regulator That Switches TNF-Induced … red voznje gradski novi sad